Agalsidase beta is used as a long-term enzyme replacement therapy in individuals with Fabry disease (a rare inherited condition that affects enzyme that breakdowns the fat, causing fat deposits in blood vessels and tissues).
Agalsidase beta is to be given intravenously (into the vein) via infusion (drip). It is delivered directly into the bloodstream via the blood vessel.
Your doctor or nurse will administer the injection for you.
Before starting your treatment, you may be given other medicines to prevent or lessen the side effects of this medicine.
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Agalsidase beta.
If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
Do not use Agalsidase beta if you ever had an allergic reaction (e.g. rashes, breathlessness, swollen eyes) to this medicine or any of its ingredients.
Inform your doctor if you have a heart problem.
Let your doctor know if you are pregnant or breastfeeding.
Agalsidase beta may cause any of the following side effects: dizziness, drowsiness, ringing in the ears, teary or watery eyes, cough, sore throat, vomiting, diarrhoea, stomach pain or discomfort, back or limb pain, joint or muscle pain, muscle spasm or tightness, weakness, feeling anxious or depressed, and skin itching.
If you experience high fever, chills, feeling hot or cold, flushing, numbness or tingling sensation in the fingers or toes, headache, nausea, chest pain, or tiredness during or after infusion with this medicine, inform your doctor immediately. Your doctor may give you certain medicines to lessen these effects, decrease the rate of infusion, or temporarily stop the infusion.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following: rashes, swollen eyes, mouth or throat, and breathlessness, these could be signs of an allergic reaction.
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Inform your doctor and pharmacist if you are taking or using any of these medicines:
- amiodarone (medicine for irregular heartbeat)
- monobenzone (medicine for vitiligo or uneven appearance of the skin due to loss of skin colour)
- chloroquine (medicine for malaria)
- gentamicin (antibiotic)
This list does not include all medicines that may interact with Agalsidase beta.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
Avoid alcohol.
Store in the refrigerator, between 2-8°C.
If you notice that the solution has changed colour or has become cloudy, do not use it. Throw it away and use a new solution.
Medicines must not be used past the expiry date.
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